MAP2K5 anticorps

N° du produit ABIN7137963

L’anticorps Lapin Polyclonal anti-MAP2K5 a été validé pour WB et ELISA. Il convient pour détecter MAP2K5 dans des échantillons de Rat.

Aperçu rapide pour MAP2K5 anticorps (ABIN7137963)

Antigène: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP2K5 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MAP2K5 anticorps

Fonction: Map2k5 Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Immunogène: Peptide sequence around aa. 311-315(K-T-Y-V-G ) derived from Rat MEK5.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAP2K5

Antigène: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Autre désignation: Map2k5

Sujet:

Background: A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7)phosphorylates and activates the JNK signal transduction pathway.

Han, J., et al. 1996. J. Biol. Chem. 271: 2886-2891.
Jiang, Y., et al. 1996. J. Biol. Chem. 271: 17920-17926.
Tournier, C., et al. 1997. Proc. Natl. Acad. Sci. USA94: 7337-7442.
Holland, P.M., et al. 1997. J. Biol. Chem. 272: 24994-24998.

Aliases: Map2k5 antibody, Mek5 antibody, Mkk5 antibody, Prkmk5 antibody, Dual specificity mitogen-activated protein kinase kinase 5 antibody, MAP kinase kinase 5 antibody, MAPKK 5 antibody, EC 2.7.12.2 antibody, MAPK/ERK kinase 5 antibody, MEK 5 antibody

UniProt: Q62862

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway