BRCA2 anticorps (pSer3291)

N° du produit ABIN7138558

Détail du produit anti-BRCA2 anticorps

Antigène: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Épitope: pSer3291

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCA2 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of Serine 3291 (F-V-S(p)-P-A) derived from Human BRCA2.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BRCA2

Antigène: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Autre désignation: BRCA2 (BRCA2 Produits)

Synonymes: anticorps BRCC2, anticorps BROVCA2, anticorps FACD, anticorps FAD, anticorps FAD1, anticorps FANCB, anticorps FANCD, anticorps FANCD1, anticorps GLM3, anticorps PNCA2, anticorps 30169, anticorps BcDNA:SD25109, anticorps CG13583, anticorps CG13584, anticorps CG30169, anticorps Dmel\\CG30169, anticorps brca2, anticorps dmbrca2, anticorps fancd1, anticorps BRCA2, anticorps brcc2, anticorps brovca2, anticorps facd, anticorps fad, anticorps fad1, anticorps fancb, anticorps AI256696, anticorps AW045498, anticorps Fancd1, anticorps RAB163, anticorps BRCA2, DNA repair associated, anticorps Breast cancer 2, early onset homolog, anticorps breast cancer 2, early onset, anticorps BRCA2, anticorps Brca2, anticorps brca2, anticorps LOC584780

Sujet:

Background:

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.

Wooster R., Nature 378:789-792(1995).
Tavtigian S.V., Nat. Genet. 12:333-337(1996).
Dunham A., Nature 428:522-528(2004).

Aliases: BRCA 2 antibody, BRCA1/BRCA2 containing complex subunit 2 antibody, Brca2 antibody, BRCA2, DNA repair associated antibody, BRCA2_HUMAN antibody, BRCC 2 antibody, BRCC2 antibody, Breast and ovarian cancer susceptibility gene early onset antibody, breast and ovarian cancer susceptibility protein 2 antibody, Breast cancer 2 early onset antibody, Breast Cancer 2 tumor suppressor antibody, Breast cancer susceptibility protein BRCA2 antibody, Breast cancer type 2 susceptibility protein antibody, BROVCA2 antibody, FACD antibody, FAD 1 antibody, FAD antibody, FAD1 antibody, FANCB antibody, FANCD 1 antibody, FANCD antibody, FANCD1 antibody, FANCD1 gene antibody, Fanconi anemia complementation group D1 antibody, Fanconi anemia group D1 protein antibody, GLM3 antibody, mutant BRCA2 antibody, OTTHUMP00000018803 antibody, OTTHUMP00000042401 antibody, PNCA2 antibody, XRCC11 antibody

UniProt: P51587

Pathways: Réparation de l'ADN, M Phase, Maintenance of Protein Location