Nibrin anticorps (pSer343)

N° du produit ABIN7138565

Détail du produit anti-Nibrin anticorps

Antigène: Nibrin (NBN)

Épitope: pSer343

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nibrin est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 343 (S-L-S(p)-Q-G) derived from Human p95/NBS1.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Nibrin

Antigène: Nibrin (NBN)

Autre désignation: NBN (NBN Produits)

Synonymes: anticorps NBN, anticorps AT-V1, anticorps AT-V2, anticorps ATV, anticorps NBS, anticorps NBS1, anticorps P95, anticorps Nbs1, anticorps im:6911679, anticorps zgc:194152, anticorps nibrin, anticorps NBN, anticorps nbn, anticorps Nbn

Sujet:

Background: Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Hsu HL, et al (2005) Oncogene, 24(31): 4956-64.
Falck J, et al. (2005) Nature, 434(7033): 605-11.
Buscemi G, et al. (2004) Oncogene, 23(46): 7691-700.
Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A, 101(33): 12130-5.

Aliases: AT V1 antibody, AT V2 antibody, ATV antibody, Cell cycle regulatory protein p95 antibody, FLJ10155 antibody, MGC87362 antibody, Nbn antibody, NBN_HUMAN antibody, NBS 1 antibody, NBS antibody, NBS1 antibody, Nibrin antibody, Nijmegen breakage syndrome 1 (nibrin) antibody, Nijmegen breakage syndrome antibody, Nijmegen breakage syndrome protein 1 antibody, p95 antibody, p95 protein of the MRE11/RAD50 complex antibody

UniProt: O60934

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response