PRKAA1 anticorps (pSer487)

N° du produit ABIN7138633

Cet anticorps anti-PRKAA1 est un anticorps Lapin Polyclonal détectant PRKAA1 dans WB, IHC, ELISA et IF. Adapté pour Humain.

Aperçu rapide pour PRKAA1 anticorps (pSer487) (ABIN7138633)

Antigène: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-PRKAA1 anticorps

Épitope: pSer487

Fonction: Phospho-PRKAA1/PRKAA2 (Ser487) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 487 (S-G- SP-V-S) derived from Human AMPKa1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PRKAA1

Antigène: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Autre désignation: PRKAA1

Sujet:

Background:

Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

Kim JE, et al. (2005) J Proteome Res. 4(4): 1339-1346.
Woods A, et al. (2003) J Biol Chem. 278(31): 28434-28442.

Aliases: 5 AMP activated protein kinase alpha 1catalytic subunit antibody, 5 AMP activated protein kinase catalytic alpha 1 chain antibody, 5' AMP activated protein kinase catalytic subunit alpha 1 antibody, 5'-AMP-activated protein kinase catalytic subunit alpha-1 antibody, AAPK1 antibody, AAPK1_HUMAN antibody, ACACA kinase antibody, acetyl CoA carboxylase kinase antibody, AI194361 antibody, AI450832 antibody, AL024255 antibody, AMP -activate kinase alpha 1 subunit antibody, AMP-activate kinase alpha 1 subunit antibody, AMP-activated protein kinase, catalytic, alpha -1 antibody, AMPK 1 antibody, AMPK alpha 1 antibody, AMPK alpha 1 chain antibody, AMPK antibody, AMPK subunit alpha 1 antibody, AMPK subunit alpha-1 antibody, AMPK1 antibody, AMPKa1 antibody, AMPKalpha1 antibody, C130083N04Rik antibody, cb116 antibody, EC 2.7.11.1 antibody, HMG CoA reductase kinase antibody, HMGCR kinase antibody, hormone sensitive lipase kinase antibody, Hydroxymethylglutaryl CoA reductase kinase antibody, im:7154392 antibody, kinase AMPK alpha1 antibody, MGC33776 antibody, MGC57364 antibody, OTTHUMP00000161795 antibody, OTTHUMP00000161796 antibody, PRKAA 1 antibody, PRKAA1 antibody, Protein kinase AMP activated alpha 1 catalytic subunit antibody, SNF1-like protein AMPK antibody, SNF1A antibody, Tau protein kinase PRKAA1 antibody, wu:fa94c10 antibody

UniProt: Q13131

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg