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FADD anticorps (pSer191)

FADD Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7138749
  • Antigène Voir toutes FADD Anticorps
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    Épitope
    • 17
    • 15
    • 15
    • 8
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer191
    Reactivité
    • 90
    • 61
    • 19
    • 18
    • 15
    Humain
    Hôte
    • 97
    • 21
    Lapin
    Clonalité
    • 93
    • 25
    Polyclonal
    Conjugué
    • 70
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FADD est non-conjugé
    Application
    • 92
    • 50
    • 32
    • 15
    • 15
    • 15
    • 15
    • 11
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
     Réactivité croisée
    Humain, Souris
    Purification
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
    Immunogène
    Peptide sequence around phosphorylation site of Serine191(R-S-G(p)-A-M) derived from Human FADD.
    Isotype
    IgG
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    Discover our top product FADD Anticorps primaire
  • Indications d'application
    WB:1:500-1:1000, IHC:1:50-1:100,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    Autre désignation
    FADD (FADD Produits)
    Synonymes
    anticorps MORT1, anticorps Mort1/FADD, anticorps Mort1, anticorps TNFRSF6, anticorps adaptor, anticorps fadd, anticorps mort1, anticorps xfadd, anticorps Fas associated via death domain, anticorps Fas (TNFRSF6)-associated via death domain, anticorps Fas associated via death domain S homeolog, anticorps Fas (tnfrsf6)-associated via death domain, anticorps FADD, anticorps Fadd, anticorps fadd.S, anticorps fadd
    Sujet

    Background:

    The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

    Sugano S., Nat. Genet. 36:40-45(2004).
    Farmer A., Submitted (MAY-2003).
    Venter J.C., Submitted (JUL-2005).

    Aliases: FADD antibody, FADD protein antibody, FADD_HUMAN antibody, Fas (TNFRSF6) associated via death domain antibody, Fas associated via death domain antibody, Fas associating death domain containing protein antibody, Fas associating protein antibody, Fas associating protein with death domain antibody, Fas TNFRSF6 associated via death domain antibody, FAS-associated death domain protein antibody, FAS-associating death domain-containing protein antibody, GIG 3 antibody, GIG3 antibody, Growth inhibiting gene 3 protein antibody, Growth-inhibiting gene 3 protein antibody, H sapiens mRNA for mediator of receptor induced toxicity antibody, Mediator of receptor induced toxicity antibody, MGC8528 antibody, MORT 1 antibody, MORT1 antibody, Protein FADD antibody

    UniProt
    Q13158
    Pathways
    Apoptose, Signalisation TLR, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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