IGF1R anticorps (pTyr1165, pTyr1166)

N° du produit ABIN7138914

L’anticorps Lapin Polyclonal anti-IGF1R a été validé pour WB, ELISA et IF. Il convient pour détecter IGF1R dans des échantillons de Humain.

Aperçu rapide pour IGF1R anticorps (pTyr1165, pTyr1166) (ABIN7138914)

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGF1R est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-IGF1R anticorps

Épitope: pTyr1165, pTyr1166

Fonction: Phospho-IGF1R (Tyr1165/Tyr1166) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K) derived from Human IGF-1R .

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IGF1R

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Autre désignation: IGF1R

Sujet:

Background: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Li S, et al. (1994) J Biol Chem, 269(51): 32558-64.

Aliases: CD221 antibody, CD221 antigen antibody, IGF 1 receptor antibody, IGF 1R antibody, IGF I receptor antibody, IGF-I receptor antibody, Igf1r antibody, IGF1R_HUMAN antibody, IGFIR antibody, IGFIRC antibody, IGFR antibody, Insulin like growth factor 1 receptor antibody, Insulin like growth factor 1 receptor precursor antibody, Insulin-like growth factor 1 receptor beta chain antibody, Insulin-like growth factor I receptor antibody, JTK13 antibody, MGC142170 antibody, MGC142172 antibody, MGC18216 antibody, Soluble IGF1R variant 1 antibody, Soluble IGF1R variant 2 antibody

UniProt: P08069

Pathways: Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy