ABL1 anticorps (pTyr204)

N° du produit ABIN7138953

L’anticorps Lapin Polyclonal anti-ABL1 a été validé pour WB et ELISA. Il convient pour détecter ABL1 dans des échantillons de Humain.

Aperçu rapide pour ABL1 anticorps (pTyr204) (ABIN7138953)

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABL1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ABL1 anticorps

Épitope: pTyr204

Fonction: Phospho-ABL1 (Tyr204) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 204 (K-L-Y(p)-V-S) derived from Human c-Abl.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ABL1

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Autre désignation: ABL1

Sujet:

Background:

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation), ANXA1 (involved in membrane anchoring), DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling), or MAPT and PXN (microtubule-binding proteins).

Meyn MA, et al. (2006) J Biol Chem 281, 30907-16
Steen H, et al. (2003) Mol Cell Proteomics 2, 138-45
Salomon AR, et al. (2003) Proc Natl Acad Sci U S A 100, 443-8

Aliases: Abelson murine leukemia viral oncogene homolog 1 antibody, Abelson tyrosine protein kinase 1 antibody, Abl 1 antibody, ABL antibody, ABL proto oncogene 1 non receptor tyrosine kinase antibody, ABL1 antibody, ABL1_HUMAN antibody, bcr/abl antibody, bcr/c abl oncogene protein antibody, c ABL antibody, c abl oncogene 1 non receptor tyrosine kinase antibody, c abl oncogene 1 receptor tyrosine kinase antibody, c ABL1 antibody, JTK7 antibody, p150 antibody, Proto oncogene tyrosine protein kinase ABL1 antibody, Proto-oncogene c-Abl antibody, Tyrosine-protein kinase ABL1 antibody, v abl Abelson murine leukemia viral oncogene homolog 1 antibody, v abl antibody

UniProt: P00519

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism