BCAR1 anticorps (pTyr410)

N° du produit ABIN7139001

L’anticorps Lapin Polyclonal anti-BCAR1 a été validé pour WB, IHC et ELISA. Il convient pour détecter BCAR1 dans des échantillons de Humain.

Aperçu rapide pour BCAR1 anticorps (pTyr410) (ABIN7139001)

Antigène: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCAR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-BCAR1 anticorps

Épitope: pTyr410

Fonction: Phospho-BCAR1 (Tyr410) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 410(G-V-Y(p)-A-V) derived from Human p130 Cas .

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BCAR1

Antigène: BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))

Autre désignation: BCAR1

Sujet:

Background:

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Katarzyna Modzelewska, J. Biol. Chem., Dec 2006, 281: 37527 - 37535.
Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006, 291: H2857 - H2863.
Sangkil Nam, Cancer Res., Oct 2005, 65: 9185 - 9189.
Norikazu Yamana, Mol. Cell. Biol., Sep 2006, 26: 6844 - 6

Aliases: BCAR 1 antibody, Bcar1 antibody, BCAR1_HUMAN antibody, Breast cancer anti estrogen resistance 1 antibody, Breast cancer anti estrogen resistance 1 protein antibody, Breast cancer anti-estrogen resistance protein 1 antibody, CAS antibody, Cas scaffolding protein family member 1 antibody, CAS1 antibody, Cass1 antibody, Crk associated substrate antibody, Crk associated substrate p130Cas antibody, CRK-associated substrate antibody, CRKAS antibody, FLJ12176 antibody, FLJ45059 antibody, p130cas antibody

UniProt: P56945

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling