ITCH anticorps (pTyr420)

N° du produit ABIN7139004

L’anticorps Lapin Polyclonal anti-ITCH a été validé pour ELISA et IHC. Il convient pour détecter ITCH dans des échantillons de Humain.

Aperçu rapide pour ITCH anticorps (pTyr420) (ABIN7139004)

Antigène: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITCH est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ITCH anticorps

Épitope: pTyr420

Fonction: Phospho-ITCH (Tyr420) Antibody

Réactivité croisée: Souris

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 420(F-I-Y(p)-G-N) derived from Human ITCH .

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ITCH

Antigène: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Autre désignation: ITCH

Sujet:

Background:

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain.

Chen X., Genomics 73:238-241(2001).
Deloukas P., Nature 414:865-871(2001).
Wood J.D., Mol. Cell. Neurosci. 11:149-160(1998).

Aliases: ADMFD antibody, AIF4 antibody, AIP4 antibody, Atrophin 1 interacting protein 4 antibody, Atrophin-1-interacting protein 4 antibody, dJ468O1.1 antibody, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) antibody, dJ468O1.1 atrophin 1 interacting protein 4 AIP4 antibody, E3 ubiquitin protein ligase Itchy homolog antibody, E3 ubiquitin-protein ligase Itchy homolog antibody, EC 6.3.2 antibody, Itch antibody, ITCH_HUMAN antibody, Itchy E3 ubiquitin protein ligase antibody, Itchy E3 ubiquitin protein ligase homolog antibody, Itchy E3 ubiquitin protein ligase homolog mouse antibody, Itchy E3 ubiquitin protein ligase, mouse, homolog of antibody, Itchy homolog E3 ubiquitin protein ligase antibody, Itchy mouse homolog E3 ubiquitin protein ligase antibody, NAPP1 antibody, NFE2 associated polypeptide 1 antibody, NFE2-associated polypeptide 1 antibody, Ubiquitin protein ligase ITCH antibody

UniProt: Q96J02

Pathways: Activation of Innate immune Response, CXCR4-mediated Signaling Events