Cortactin anticorps (pTyr466)

N° du produit ABIN7139010

L’anticorps Lapin Polyclonal anti-Cortactin a été validé pour WB et ELISA. Il convient pour détecter Cortactin dans des échantillons de Humain.

Aperçu rapide pour Cortactin anticorps (pTyr466) (ABIN7139010)

Antigène: Cortactin (CTTN)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cortactin est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Cortactin anticorps

Épitope: pTyr466

Fonction: Phospho-CTTN (Tyr466) Antibody

Réactivité croisée: Souris

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 466 (P-V-Y(p)-E-T) derived from Human CORTACTIN.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Cortactin

Antigène: Cortactin (CTTN)

Autre désignation: CTTN

Sujet:

Background:

Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Luo C, et al. (2006) J Biol Chem , 281(40):30081-30093
Head JA, et al. (2003) Mol Biol Cell ,14(8):3216-3229
Li Y, et al. (2000) J Biol Chem , 275(47): 37187-37193
Kinley AW, et al. (2003) Curr Biol , 13(5): 384-393

Aliases: Amplaxin antibody, CTTN antibody, EMS 1 antibody, EMS1 antibody, FLJ34459 antibody, Mammary tumor and squamous cell carcinoma associated antibody, Oncogene EMS1 antibody, p80/85 src substrate antibody, Src substrate cortactin antibody, SRC8_HUMAN antibody

UniProt: Q14247

Pathways: Signalisation MAPK