MUSK anticorps (pTyr755)

N° du produit ABIN7139062

Cet anticorps anti-MUSK est un anticorps Lapin Polyclonal détectant MUSK dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour MUSK anticorps (pTyr755) (ABIN7139062)

Antigène: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUSK est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MUSK anticorps

Épitope: pTyr755

Fonction: Phospho-MUSK (Tyr755) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 755(A-D-Y(p)-Y-K) derived from Human MuSK .

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MUSK

Antigène: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Autre désignation: MUSK

Sujet:

Background:

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.

Valenzuela D.M., Neuron 15:573-584(1995).
Humphray S.J., Nature 429:369-374(2004).
Bergamin E., Mol. Cell 39:100-109(2010).

Aliases: CMS9 antibody, FADS antibody, MDK 4 antibody, MDK4 antibody, MGC126323 antibody, MGC126324 antibody, Muscle antibody, Muscle associated receptor tyrosine kinase antibody, Muscle skeletal receptor tyrosine kinase antibody, Muscle skeletal receptor tyrosine protein kinase antibody, Muscle specific kinase receptor antibody, Muscle specific tyrosine kinase receptor antibody, Muscle specific tyrosine protein kinase receptor antibody, Muscle-specific kinase receptor antibody, Muscle-specific tyrosine-protein kinase receptor antibody, MuSK antibody, MUSK_HUMAN antibody, Neural fold somite kinase 1 antibody, Neural fold somite kinase 2 antibody, Neural fold somite kinase 3 antibody, Neural fold somite kinase1 antibody, Neural fold somite kinase2 antibody, Neural fold somite kinase3 antibody, Nsk 1 antibody, Nsk 2 antibody, Nsk 3 antibody, Nsk1 antibody, Nsk2 antibody, Nsk3 antibody, Receptor tyrosine kinase MuSK antibody, Skeletal muscle receptor tyrosine kinase antibody, skeletal receptor tyrosine-protein kinase antibody

UniProt: O15146

Pathways: Signalisation RTK, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development