PSMD14 anticorps (Regulatory Subunit)

N° du produit ABIN7139700

L’anticorps anti-PSMD14 Polyclonal Lapin est utilisé pour la détection de PSMD14 dans des échantillons de Humain. Il a été validé pour WB, ELISA, IHC et IF.

Aperçu rapide pour PSMD14 anticorps (Regulatory Subunit) (ABIN7139700)

Antigène: PSMD14 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14 (PSMD14))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMD14 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-PSMD14 anticorps

Épitope: AA 264-283, Regulatory Subunit

Fonction: PSMD14 Antibody

Réactivité croisée: Rat

Purification: Antigen Affinity Purified

Immunogène: Peptide sequence from Human 26S proteasome non-ATPase regulatory subunit 14 protein (264-283AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PSMD14

Antigène: PSMD14 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14 (PSMD14))

Autre désignation: PSMD14

Sujet:

Background: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves \\\'Lys-63\\\'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving \\\'Lys-63\\\'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Aliases: 26S proteasome non-ATPase regulatory subunit 14 antibody, 26S proteasome regulatory subunit rpn11 antibody, 26S proteasome-associated PAD1 homolog 1 antibody, 26S proteasome-associated PAD1 homolog antibody, PAD1 antibody, PAD1, yeast, homolog of antibody, POH1 antibody, Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 antibody, Proteasome 26S subunit non ATPase 14 antibody, PSDE_HUMAN antibody, Psmd14 antibody, RPN11 antibody, Testis tissue sperm binding protein Li 69n antibody

UniProt: O00487

Pathways: Mitotic G1-G1/S Phases, DNA Replication, M Phase, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Ubiquitin Proteasome Pathway