PEN2 anticorps (AA 39-57)

N° du produit ABIN7139851

Cet anticorps anti-PEN2 est un anticorps Lapin Polyclonal détectant PEN2 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour PEN2 anticorps (AA 39-57) (ABIN7139851)

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEN2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PEN2 anticorps

Épitope: AA 39-57

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Peptide sequence from Human Gamma-secretase subunit PEN-2 protein (39-57AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PEN2

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Autre désignation: PSENEN

Sujet:

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).

Aliases: Gamma secretase subunit PEN 2 antibody, Gamma Secretase Subunit PEN2 antibody, Gamma-secretase subunit PEN-2 antibody, Hematopoietic stem/progenitor cells protein MDS033 antibody, MDS033 antibody, MSTP064 antibody, PEN 2 antibody, PEN2_HUMAN antibody, Presenilin Enhancer 2 antibody, Presenilin enhancer 2 homolog antibody, Presenilin enhancer protein 2 antibody, PSEN2 antibody, psenen antibody

UniProt: Q9NZ42

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway