RAGE anticorps (AA 23-342)

N° du produit ABIN7143554

Cet anticorps Lapin Polyclonal détecte spécifiquement RAGE dans IHC, ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour RAGE anticorps (AA 23-342) (ABIN7143554)

Antigène: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAGE est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-RAGE anticorps

Épitope: AA 23-342

Fonction: AGER Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RAGE

Antigène: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Autre désignation: AGER

Sujet:

Background: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.

Aliases: Advanced glycosylation end product-specific receptor antibody, Ager antibody, DAMA 358M23.4 antibody, MGC2235 antibody, MGC22357 antibody, RAGE_HUMAN antibody, Receptor for advanced glycation end products antibody, Receptor for advanced glycosylation end products antibody

UniProt: Q15109

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins