Axin anticorps (AA 418-707) (HRP)

N° du produit ABIN7145126

Cet anticorps Lapin Polyclonal détecte spécifiquement Axin dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour Axin anticorps (AA 418-707) (HRP) (ABIN7145126)

Antigène: Axin (AXIN1) (Axin 1 (AXIN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Axin est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-Axin anticorps (HRP)

Épitope: AA 418-707

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Axin-1 protein (418-707AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Axin

Antigène: Axin (AXIN1) (Axin 1 (AXIN1))

Autre désignation: AXIN1

Sujet:

Background: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

Aliases: AI316800 antibody, AXIN antibody, Axin 1 antibody, Axin-1 antibody, axin1 antibody, AXIN1_HUMAN antibody, Axis inhibition protein 1 antibody, Axis Inhibitor 1 antibody, Fu antibody, fused antibody, Fused, mouse, homolog of antibody, hAxin antibody, Kb antibody, Ki antibody, kinky antibody, knobbly antibody, MGC132911 antibody, MGC52315 antibody, PPP1R49 antibody, Protein Fused antibody, Protein phosphatase 1 regulatory subunit 49 antibody

UniProt: O15169

Pathways: Signalisation WNT, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling