BIRC2 anticorps (AA 1-300)

N° du produit ABIN7145198

Détail du produit anti-BIRC2 anticorps

Antigène: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Épitope: AA 1-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIRC2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Baculoviral IAP repeat-containing protein 2 protein (1-300AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BIRC2

Antigène: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Autre désignation: BIRC2 (BIRC2 Produits)

Synonymes: anticorps API1, anticorps HIAP2, anticorps Hiap-2, anticorps MIHB, anticorps RNF48, anticorps c-IAP1, anticorps cIAP1, anticorps Api2, anticorps rIAP1, anticorps IAP1, anticorps ITA, anticorps AW146227, anticorps Api1, anticorps Birc3, anticorps HIAP1, anticorps IAP2, anticorps MIAP1, anticorps MIAP2, anticorps MIHC, anticorps cIAP2, anticorps mcIAP1, anticorps ciap-1, anticorps birc3, anticorps api1, anticorps birc2, anticorps c-iap1, anticorps ciap1, anticorps hiap-2, anticorps hiap2, anticorps mihb, anticorps rnf48, anticorps baculoviral IAP repeat containing 2, anticorps baculoviral IAP repeat-containing 2, anticorps baculoviral IAP repeat containing 2 L homeolog, anticorps BIRC2, anticorps Birc2, anticorps birc2, anticorps birc2.L

Sujet:

Background: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Aliases: API 1 antibody, API1 antibody, Apoptosis inhibitor 1 antibody, Baculoviral IAP repeat containing 2 antibody, Baculoviral IAP repeat containing protein 2 antibody, Baculoviral IAP repeat-containing protein 2 antibody, BIRC 2 antibody, BIRC2 antibody, BIRC2_HUMAN antibody, C IAP1 antibody, C-IAP1 antibody, Cellular inhibitor of apoptosis 1 antibody, cellular inhibitor of apoptosis protein 1 antibody, cIAP 1 antibody, cIAP1 antibody, HIAP 2 antibody, HIAP-2 antibody, HIAP2 antibody, IAP 2 antibody, IAP homolog B antibody, IAP-2 antibody, IAP2 antibody, Inhibitor of apoptosis protein 2 antibody, MIHB antibody, NFR2 TRAF signalling complex protein antibody, RING finger protein 48 antibody, RNF 48 antibody, RNF48 antibody, TNFR2 TRAF signaling complex protein 2 antibody, TNFR2-TRAF-signaling complex protein 2 antibody

UniProt: Q13490

Pathways: Apoptose, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades