CHP anticorps (AA 2-195) (HRP)

N° du produit ABIN7146264

L’anticorps Lapin Polyclonal anti-CHP a été validé pour ELISA. Il convient pour détecter CHP dans des échantillons de Humain.

Aperçu rapide pour CHP anticorps (AA 2-195) (HRP) (ABIN7146264)

Antigène: CHP (Calcium Binding Protein P22 (CHP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHP est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-CHP anticorps (HRP)

Épitope: AA 2-195

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Calcineurin B homologous protein 1 protein (2-195AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CHP

Antigène: CHP (Calcium Binding Protein P22 (CHP))

Autre désignation: CHP1

Sujet:

Background: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH . Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

Aliases: Calcineurin B homolog antibody, Calcineurin B homologous protein antibody, Calcineurin homologous protein antibody, Calcineurin like EF hand protein 1 antibody, Calcium binding protein CHP antibody, Calcium binding protein p22 antibody, Calcium-binding protein CHP antibody, Calcium-binding protein p22 antibody, chp antibody, CHP1_HUMAN antibody, Sid 470 antibody, Sid470 antibody, SLC9A1 binding protein antibody, SLC9A1BP antibody, Wrch2 antibody

UniProt: Q99653

Pathways: Proton Transport, Regulation of Carbohydrate Metabolic Process, VEGF Signaling