COPS4 anticorps (AA 1-310)

N° du produit ABIN7148496

L’anticorps Lapin Polyclonal anti-COPS4 a été validé pour WB, ELISA et IHC. Il convient pour détecter COPS4 dans des échantillons de Humain.

Aperçu rapide pour COPS4 anticorps (AA 1-310) (ABIN7148496)

Antigène: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-COPS4 anticorps

Épitope: AA 1-310

Fonction: COPS4 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human COP9 signalosome complex subunit 4 protein (1-310AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur COPS4

Antigène: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Autre désignation: COPS4

Sujet:

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Aliases: CH4 antibody, COP9 (constitutive photomorphogenic) homolog subunit 4 antibody, COP9 complex homolog subunit 4 antibody, COP9 complex S4 antibody, COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antibody, COP9 constitutive photomorphogenic homolog subunit 4 antibody, COP9 signalosome complex subunit 4 antibody, COP9 signalosome subunit 4 antibody, COPS4 antibody, CSN complex subunit 4 antibody, CSN4 antibody, CSN4 SCHPO antibody, CSN4_HUMAN antibody, DCH4 antibody, JAB1 containing signalosome subunit 4 antibody, JAB1-containing signalosome subunit 4 antibody, MGC94896 antibody, SGN4 antibody, Signalosome subunit 4 antibody

UniProt: Q9BT78

Pathways: Cycle Cellulaire