Cullin 1 anticorps (AA 500-776)

N° du produit ABIN7148748

Détail du produit anti-Cullin 1 anticorps

Antigène: Cullin 1 (CUL1)

Épitope: AA 500-776

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity purified

Immunogène: Recombinant Human Cullin-1 protein (500-776AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Cullin 1

Antigène: Cullin 1 (CUL1)

Autre désignation: CUL1 (CUL1 Produits)

Synonymes: anticorps LOC100282292, anticorps Cullin-1, anticorps Cul1, anticorps zgc:55747, anticorps zgc:77500, anticorps wu:fc13a10, anticorps cullin-1, anticorps ATCUL1, anticorps AUXIN RESISTANT 6, anticorps AXR6, anticorps T10P11.26, anticorps T10P11_26, anticorps cullin 1, anticorps cul1, anticorps wu:fi43h07, anticorps wu:fj43a08, anticorps zgc:111899, anticorps zgc:55483, anticorps Cul-1, anticorps cullin 1, anticorps cullin-1, anticorps Cullin 1, anticorps Cullin-1, anticorps cullin 1a, anticorps cullin 1 S homeolog, anticorps cullin 1b, anticorps CUL1, anticorps LOC100282292, anticorps cul1, anticorps ATEG_00491, anticorps EDI_072700, anticorps EDI_264400, anticorps SJAG_02591, anticorps BDBG_03785, anticorps Cul1, anticorps cul1a, anticorps cul1.S, anticorps cul-1, anticorps cul1b

Sujet:

Background: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at \\\'Lys-21\\\' and \\\'Lys-22\\\', the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Aliases: CUL 1 antibody, CUL-1 antibody, CUL1 antibody, CUL1_HUMAN antibody, Cullin-1 antibody, Cullin1 antibody, MGC149834 antibody, MGC149835 antibody

UniProt: Q13616

Pathways: Cycle Cellulaire, Signalisation Hedgehog, Mitotic G1-G1/S Phases, Regulation of Cell Size