ATF6 anticorps (AA 1-194)

N° du produit ABIN7148805

L’anticorps Lapin Polyclonal anti-ATF6 a été validé pour IHC, ELISA et IF. Il convient pour détecter ATF6 dans des échantillons de Humain.

Aperçu rapide pour ATF6 anticorps (AA 1-194) (ABIN7148805)

Antigène: ATF6 (Activating Transcription Factor 6 (ATF6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF6 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-ATF6 anticorps

Épitope: AA 1-194

Fonction: ATF6 Antibody

Purification: Antigen Affinity purified & Affinity purified

Pureté: >95 %

Immunogène: Recombinant Human Cyclic AMP-dependent transcription factor ATF-6 alpha protein (1-194AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ATF6

Antigène: ATF6 (Activating Transcription Factor 6 (ATF6))

Autre désignation: ATF6

Sujet:

Background: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5\'-CCAC[GA]-3\'half of the ER stress response element (ERSE) (5\'-CCAAT-N(9)-CCAC[GA]-3\') and of ERSE II (5\'-ATTGG-N-CCACG-3\'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Aliases: Activating transcription factor 6 alpha antibody, Activating transcription factor 6 antibody, ATF 6 antibody, ATF6 alpha antibody, ATF6 antibody, ATF6-alpha antibody, ATF6A antibody, ATF6A_HUMAN antibody, cAMP dependent transcription factor ATF 6 alpha antibody, cAMP-dependent transcription factor ATF-6 alpha antibody, Cyclic AMP dependent transcription factor ATF 6 alpha antibody, DKFZp686P2194 antibody, ESTM49 antibody, FLJ21663 antibody, Processed cyclic AMP dependent transcription factor ATF 6 alpha antibody, Processed cyclic AMP-dependent transcription factor ATF-6 alpha antibody

UniProt: P18850

Pathways: ER-Nucleus Signaling, Unfolded Protein Response