CISH anticorps (AA 1-257)

N° du produit ABIN7149303

L’anticorps Lapin Polyclonal anti-CISH a été validé pour IHC et ELISA. Il convient pour détecter CISH dans des échantillons de Humain.

Aperçu rapide pour CISH anticorps (AA 1-257) (ABIN7149303)

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CISH est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-CISH anticorps

Épitope: AA 1-257

Fonction: CISH Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Cytokine-inducible SH2-containing protein (1-257AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CISH

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Autre désignation: CISH

Sujet:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Aliases: BACTS2 antibody, cis 1 antibody, CIS antibody, CIS-1 antibody, CIS1 antibody, Cish antibody, CISH_HUMAN antibody, Cytokine inducible inhibitor of signaling type 1B antibody, Cytokine inducible SH2 containing protein antibody, Cytokine-inducible SH2-containing protein antibody, G18 antibody, Protein G18 antibody, SOCS antibody, Suppressor of cytokine signaling antibody

UniProt: Q9NSE2

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus