DIABLO anticorps (AA 168-236)

N° du produit ABIN7149840

L’anticorps Lapin Polyclonal anti-DIABLO a été validé pour ELISA, IHC et IF. Il convient pour détecter DIABLO dans des échantillons de Humain.

Aperçu rapide pour DIABLO anticorps (AA 168-236) (ABIN7149840)

Antigène: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIABLO est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-DIABLO anticorps

Épitope: AA 168-236

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Diablo homolog, mitochondrial protein (168-236AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DIABLO

Antigène: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Autre désignation: DIABLO

Sujet:

Background: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Aliases: 0610041G12Rik antibody, DBLOH_HUMAN antibody, DBOH antibody, DFNA64 antibody, diablo antibody, Diablo homolog (Drosophila) antibody, Diablo homolog antibody, Diablo homolog mitochondrial antibody, Diablo IAP binding mitochondrial protein antibody, Diablo like protein antibody, DIABLO S antibody, Direct IAP binding protein with low pI antibody, Direct IAP-binding protein with low pI antibody, FLJ10537 antibody, FLJ25049 antibody, mitochondrial antibody, Mitochondrial Smac protein antibody, Second mitochondria derived activator of caspase antibody, Second mitochondria-derived activator of caspase antibody, second mitochondrial activator of caspases antibody, SMAC 3 antibody, Smac antibody, Smac protein antibody, SMAC3 antibody

UniProt: Q9NR28

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity