CLK2 anticorps (AA 240-499)

N° du produit ABIN7150731

L’anticorps Lapin Polyclonal anti-CLK2 a été validé pour WB, ELISA et IHC. Il convient pour détecter CLK2 dans des échantillons de Humain.

Aperçu rapide pour CLK2 anticorps (AA 240-499) (ABIN7150731)

Antigène: CLK2 (CDC-Like Kinase 2 (CLK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-CLK2 anticorps

Épitope: AA 240-499

Fonction: CLK2 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Dual specificity protein kinase CLK2 protein (240-499AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CLK2

Antigène: CLK2 (CDC-Like Kinase 2 (CLK2))

Autre désignation: CLK2

Sujet:

Background: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Aliases: CDC like kinase 2 antibody, CDC-like kinase 2 antibody, CLK 2 antibody, CLK kinase antibody, CLK2 antibody, Clk2 Scamp3 antibody, CLK2_HUMAN antibody, Dual specificity protein kinase CLK2 antibody, hCLK 2 antibody, hCLK2 antibody, Tu52 antibody

UniProt: P49760

Pathways: Regulation of Carbohydrate Metabolic Process