EGLN1 anticorps (AA 301-426)

N° du produit ABIN7151443

Cet anticorps anti-EGLN1 est un anticorps Lapin Polyclonal détectant EGLN1 dans WB, IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour EGLN1 anticorps (AA 301-426) (ABIN7151443)

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGLN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-EGLN1 anticorps

Épitope: AA 301-426

Fonction: EGLN1 Antibody

Réactivité croisée: Rat

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Egl nine homolog 1 protein (301-426AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EGLN1

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Autre désignation: EGLN1

Sujet:

Background: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recognized via a LXXLAP motif.

Aliases: C1ORF12 antibody, Chromosome 1 Open Reading Frame 12 antibody, DKFZp761F179 antibody, ECYT 3 antibody, ECYT3 antibody, Egl 9 family hypoxia inducible factor 1 antibody, EGL 9 homolog of C. elegans 1 antibody, EGL nine (C.elegans) homolog 1 antibody, Egl nine homolog 1 (C. elegans) antibody, Egl nine homolog 1 antibody, Egl nine like protein 1 antibody, EGLN 1 antibody, Egln1 antibody, EGLN1_HUMAN antibody, HIF PH2 antibody, HIF Prolyl Hydroxylase 2 antibody, HIF-PH2 antibody, HIF-prolyl hydroxylase 2 antibody, HIFP4H 2 antibody, HIFPH2 antibody, HPH 2 antibody, HPH-2 antibody, HPH2 antibody, Hypoxia inducible factor prolyl hydroxylase 2 antibody, Hypoxia-inducible factor prolyl hydroxylase 2 antibody, ORF13 antibody, P4H2 antibody, PHD 2 antibody, PhD2 antibody, PNAS 118 antibody, PNAS 137 antibody, Prolyl Hydroxylase Domain Containing Protein 2 antibody, Prolyl hydroxylase domain-containing protein 2 antibody, Rat Homolog of SM20 antibody, SM 20 antibody, SM-20 antibody, SM20 antibody, Zinc finger MYND domain containing protein 6 antibody, ZMYND6 antibody

UniProt: Q9GZT9

Pathways: cAMP Metabolic Process, L'effet Warburg