EMP2 anticorps (AA 22-66) (Biotin)

N° du produit ABIN7151930

Cet anticorps Lapin Polyclonal détecte spécifiquement EMP2 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour EMP2 anticorps (AA 22-66) (Biotin) (ABIN7151930)

Antigène: EMP2 (Epithelial Membrane Protein 2 (EMP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EMP2 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-EMP2 anticorps (Biotin)

Épitope: AA 22-66

Fonction: EMP2 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Epithelial membrane protein 2 protein (22-66AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EMP2

Antigène: EMP2 (Epithelial Membrane Protein 2 (EMP2))

Autre désignation: EMP2

Sujet:

Background: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role in glomerular filtration (By similarity).

Aliases: EMP 2 antibody, EMP-2 antibody, EMP2 antibody, EMP2_HUMAN antibody, Epithelial membrane protein 2 antibody, Protein XMP antibody

UniProt: P54851