FAK anticorps (pTyr576, pTyr577) (Cy5)

N° du produit ABIN711090

Cet anticorps anti-FAK Polyclonal Lapin conjugué à Cy5 (ABIN711090) détecte spécifiquement FAK dans WB, IF (p) et IF (cc). L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour FAK anticorps (pTyr576, pTyr577) (Cy5) (ABIN711090)

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAK est conjugé à/à la Cy5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-FAK anticorps (Cy5)

Épitope: pTyr576, pTyr577

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human PTK2 around the phosphorylation site of Tyr576+Tyr577

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FAK

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Autre désignation: PTK2+

Sujet:

Synonyms: PTK2 phospho Y576/Y577, FADK 1, FADK, FAK 1, FAK related non kinase polypeptide, FAK1, Focal adhesion kinase 1, FRNK, pp125FAK, Protein tyrosine kinase 2, Protein Tyrosine Kinase Cytoplasmic, PTK 2, PTK2, PTK2 protein tyrosine kinase 2.

Background: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane, Peripheral membrane protein, Cytoplasmic side. Note=Constituent of focal adhesions.

ID gène: 5747

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling