FZD1 anticorps (AA 73-322)

N° du produit ABIN7153175

Cet anticorps Lapin Polyclonal détecte spécifiquement FZD1 dans ELISA, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour FZD1 anticorps (AA 73-322) (ABIN7153175)

Antigène: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-FZD1 anticorps

Épitope: AA 73-322

Fonction: FZD1 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Frizzled-1 protein (73-322AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FZD1

Antigène: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Autre désignation: FZD1

Sujet:

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Aliases: Chfz-1 antibody, Dfrizzled-1 antibody, DKFZp564G072 antibody, FLJ95923 antibody, Frizzled 1 antibody, Frizzled homolog 1 (Drosophila) antibody, Frizzled homolog 1 antibody, Frizzled-1 antibody, Fz receptor 1 antibody, Fz-1 antibody, Fz1 antibody, FZD1 antibody, FZD1_HUMAN antibody, FzE1 antibody, hFz1 antibody, Rfz1 antibody, Wnt receptor antibody, Xfrizzled-1 antibody

UniProt: Q9UP38

Pathways: Signalisation WNT, Asymmetric Protein Localization