FZD8 anticorps (AA 55-233)

N° du produit ABIN7153193

Cet anticorps Lapin Polyclonal détecte spécifiquement FZD8 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour FZD8 anticorps (AA 55-233) (ABIN7153193)

Antigène: FZD8 (Frizzled Family Receptor 8 (FZD8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-FZD8 anticorps

Épitope: AA 55-233

Fonction: FZD8 Antibody

Réactivité croisée: Souris

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Frizzled-8 protein (55-233AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FZD8

Antigène: FZD8 (Frizzled Family Receptor 8 (FZD8))

Autre désignation: FZD8

Sujet:

Background: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Aliases: Frizzled 8 seven transmembrane spanning receptor antibody, frizzled 8, seven transmembrane spanning receptor antibody, Frizzled family receptor 8 antibody, frizzled homolog 8 (Drosophila) antibody, Frizzled homolog 8 antibody, Frizzled-8 antibody, FZ 8 antibody, Fz-8 antibody, FZ8 antibody, FZD 8 antibody, FZD8 antibody, FZD8_HUMAN antibody, hFZ 8 antibody, hFz8 antibody, HGNC4046 antibody, Homolog of Drosophila Frizzled 8 antibody

UniProt: Q9H461

Pathways: Signalisation WNT