GRB10 anticorps (AA 15-180)

N° du produit ABIN7154494

Cet anticorps anti-GRB10 est un anticorps Lapin Polyclonal détectant GRB10 dans ELISA, IHC et IF. Adapté pour Humain.

Aperçu rapide pour GRB10 anticorps (AA 15-180) (ABIN7154494)

Antigène: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB10 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-GRB10 anticorps

Épitope: AA 15-180

Fonction: GRB10 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Growth factor receptor-bound protein 10 protein (15-180AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur GRB10

Antigène: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Autre désignation: GRB10

Sujet:

Background: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Aliases: grb 10 antibody, GRB IR antibody, grb-10 antibody, GRB10 adapter protein antibody, GRB10 adaptor protein antibody, GRB10 antibody, GRB10_HUMAN antibody, GRBIR antibody, Growth factor receptor bound protein 10 antibody, Growth factor receptor-bound protein 10 antibody, Insulin receptor binding protein antibody, Insulin receptor binding protein GRB IR antibody, Insulin receptor-binding protein Grb-IR antibody, IRBP antibody, KIAA0207 antibody, Maternally expressed gene 1 antibody, MEG1 antibody, RSS antibody

UniProt: Q13322

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2