SIX Homeobox 1 anticorps (AA 144-262)

N° du produit ABIN7155848

Cet anticorps Lapin Polyclonal détecte spécifiquement SIX Homeobox 1 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour SIX Homeobox 1 anticorps (AA 144-262) (ABIN7155848)

Antigène: SIX Homeobox 1 (SIX1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIX Homeobox 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SIX Homeobox 1 anticorps

Épitope: AA 144-262

Fonction: SIX1 Antibody

Réactivité croisée: Souris, Rat

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Homeobox protein SIX1 protein (144-262AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SIX Homeobox 1

Antigène: SIX Homeobox 1 (SIX1)

Autre désignation: SIX1

Sujet:

Background: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5\\\'-TCA[AG][AG]TTNC-3\\\' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.

Aliases: BOS3 antibody, DFNA23 antibody, Homeobox protein SIX1 antibody, OTTHUMP00000179042 antibody, Sine oculis homeobox homolog 1 antibody, SIX homeobox 1 antibody, SIX1 antibody, SIX1_HUMAN antibody, TIP39 antibody

UniProt: Q15475

Pathways: Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development