HIPK2 anticorps (AA 816-977)

N° du produit ABIN7155865

Cet anticorps anti-HIPK2 est un anticorps Lapin Polyclonal détectant HIPK2 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour HIPK2 anticorps (AA 816-977) (ABIN7155865)

Antigène: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIPK2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-HIPK2 anticorps

Épitope: AA 816-977

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Homeodomain-interacting protein kinase 2 protein (816-977AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HIPK2

Antigène: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Autre désignation: HIPK2

Sujet:

Background: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.

Aliases: hHIPk 2 antibody, hHIPk2 antibody, HIPK 2 antibody, Hipk2 antibody, HIPK2_HUMAN antibody, Homeodomain interacting protein kinase 2 antibody, Homeodomain-interacting protein kinase 2 antibody, Nbak1 antibody, Nuclear body-associated kinase 1 antibody, PRO0593 antibody, Sialophorin tail-associated nuclear serine/threonine-protein kinase antibody, Stank antibody

UniProt: Q9H2X6

Pathways: Cycle Cellulaire