KPNA4 anticorps (AA 51-239) (FITC)

N° du produit ABIN7156124

Cet anticorps Lapin Polyclonal détecte spécifiquement KPNA4 dans . Il présente une réactivité envers Humain.

Aperçu rapide pour KPNA4 anticorps (AA 51-239) (FITC) (ABIN7156124)

Antigène: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA4 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-KPNA4 anticorps (FITC)

Épitope: AA 51-239

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Importin subunit alpha-3 protein (51-239AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KPNA4

Antigène: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Autre désignation: KPNA4

Sujet:

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Aliases: FLJ31113 antibody, IMA3_HUMAN antibody, Importin alpha 3 antibody, Importin alpha 4 subunit antibody, Importin alpha Q1 antibody, Importin subunit alpha 3 antibody, Importin subunit alpha-3 antibody, IPO A3 antibody, IPOA 3 antibody, IPOA3 antibody, Karyopherin alpha 4 (importin alpha 3) antibody, Karyopherin alpha 4 antibody, Karyopherin alpha 4 importin alpha 3 antibody, Karyopherin alpha 4 subunit antibody, Karyopherin subunit alpha 4 antibody, Karyopherin subunit alpha-4 antibody, KPNA 4 antibody, Kpna4 antibody, MGC12217 antibody, MGC26703 antibody, OTTHUMP00000213880 antibody, QIP 1 antibody, Qip1 antibody, Qip1 protein antibody, SRP 3 antibody, SRP3 antibody

UniProt: O00629

Pathways: Protein targeting to Nucleus