INSIG1 anticorps (AA 1-87) (Biotin)

N° du produit ABIN7156349

Cet anticorps Lapin Polyclonal détecte spécifiquement INSIG1 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour INSIG1 anticorps (AA 1-87) (Biotin) (ABIN7156349)

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INSIG1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-INSIG1 anticorps (Biotin)

Épitope: AA 1-87

Fonction: INSIG1 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Insulin-induced gene 1 protein (1-87AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur INSIG1

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Autre désignation: INSIG1

Sujet:

Background: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

Aliases: CL 6 antibody, CL6 antibody, INSI1_HUMAN antibody, INSIG 1 antibody, INSIG 1 membrane protein antibody, INSIG-1 antibody, insig1 antibody, INSIG1 membrane protein antibody, Insulin induced gene 1 antibody, Insulin induced gene 1 protein antibody, Insulin-induced gene 1 protein antibody, MGC1405 antibody

UniProt: O15503

Pathways: ER-Nucleus Signaling