KIT Ligand anticorps (AA 26-214)

N° du produit ABIN7157685

L’anticorps Lapin Polyclonal anti-KIT Ligand a été validé pour WB et ELISA. Il convient pour détecter KIT Ligand dans des échantillons de Humain.

Aperçu rapide pour KIT Ligand anticorps (AA 26-214) (ABIN7157685)

Antigène: KIT Ligand (KITLG)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIT Ligand est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-KIT Ligand anticorps

Épitope: AA 26-214

Fonction: KITLG Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Kit ligand protein (26-214AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KIT Ligand

Antigène: KIT Ligand (KITLG)

Autre désignation: KITLG

Sujet:

Background: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Aliases: C kit ligand antibody, C-kit ligand antibody, Ckit ligand antibody, DCUA antibody, DFNA69 antibody, DKFZp686F2250 antibody, familial progressive hyperpigmentation 2 antibody, FPH2 antibody, FPHH antibody, KIT ligand antibody, Kitl antibody, KITLG antibody, KL 1 antibody, KL1 antibody, Mast cell growth factor antibody, MGF antibody, MGF stem cell factor antibody, SCF antibody, SCF_HUMAN antibody, SF antibody, SHEP7 antibody, sKITLG antibody, Soluble KIT ligand antibody, Steel factor antibody, steel, mouse, homolog of antibody, Stem cell factor antibody, Stem cell factor precursor antibody

UniProt: P21583

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway