NOTCH2 anticorps (AA 59-250)

N° du produit ABIN7161298

Cet anticorps anti-NOTCH2 est un anticorps Lapin Polyclonal détectant NOTCH2 dans ELISA, IHC et IF. Adapté pour Humain.

Aperçu rapide pour NOTCH2 anticorps (AA 59-250) (ABIN7161298)

Antigène: NOTCH2 (Notch 2 (NOTCH2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOTCH2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-NOTCH2 anticorps

Épitope: AA 59-250

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Neurogenic locus notch homolog protein 2 protein (59-250AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NOTCH2

Antigène: NOTCH2 (Notch 2 (NOTCH2))

Autre désignation: NOTCH2

Sujet:

Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737).

Aliases: AGS2 antibody, hN2 antibody, Motch B antibody, N2 antibody, N2ECD antibody, N2ICD antibody, neurogenic locus notch homolog protein 2 antibody, NOTC2_HUMAN antibody, Notch 2 antibody, Notch 2 intracellular domain antibody, Notch Drosophila homolog 2 antibody, Notch homolog 2 antibody, Notch homolog 2 Drosophila antibody, Notch2 antibody

UniProt: Q04721

Pathways: Signalisation Notch, Stem Cell Maintenance