TNIK anticorps (pSer764) (Cy7)

N° du produit ABIN711947

L’anticorps Lapin Polyclonal anti-TNIK a été validé pour IF (p) et IF (cc). Il convient pour détecter TNIK dans des échantillons de Souris et Rat.

Aperçu rapide pour TNIK anticorps (pSer764) (Cy7) (ABIN711947)

Antigène: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNIK est conjugé à/à la Cy7

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-TNIK anticorps (Cy7)

Épitope: pSer764

Specificité: Phosphorylation site corresponds to Ser735 in mouse

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human TNIK around the phosphorylation site of Ser764

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TNIK

Antigène: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Autre désignation: TNIK

Sujet:

Synonyms: TRAF2 and NCK-interacting protein kinase, TNIK, KIAA0551

Background: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

ID gène: 23043

UniProt: Q9UKE5