NUMBL anticorps (AA 447-576) (HRP)

N° du produit ABIN7162088

Cet anticorps Lapin Polyclonal détecte spécifiquement NUMBL dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour NUMBL anticorps (AA 447-576) (HRP) (ABIN7162088)

Antigène: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMBL est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-NUMBL anticorps (HRP)

Épitope: AA 447-576

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Numb-like protein (447-576AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NUMBL

Antigène: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Autre désignation: NUMBL

Sujet:

Background: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the \'Lys-48\'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Aliases: CAG 3A antibody, CAG3A antibody, CTG 3a antibody, CTG3a antibody, NBL antibody, NUMB Drosophilia Homolog Like antibody, Numb homolog (Drosophila) like antibody, Numb homolog like antibody, Numb like protein antibody, NUMB R antibody, Numb-like protein antibody, Numb-R antibody, Numb-related gene antibody, Numb-related protein antibody, NUMBL antibody, NUMBL_HUMAN antibody, NUMBLIKE antibody, NUMBR antibody, TNRC 23 antibody, TNRC23 antibody, Trinucleotide repeat-containing gene 23 antibody

UniProt: Q9Y6R0

Pathways: Cell-Cell Junction Organization