ETHE1 anticorps (AA 8-254) (Biotin)

N° du produit ABIN7163018

Cet anticorps Lapin Polyclonal détecte spécifiquement ETHE1 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour ETHE1 anticorps (AA 8-254) (Biotin) (ABIN7163018)

Antigène: ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ETHE1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-ETHE1 anticorps (Biotin)

Épitope: AA 8-254

Fonction: ETHE1 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Persulfide dioxygenase ETHE1, mitochondrial protein (8-254AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ETHE1

Antigène: ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))

Autre désignation: ETHE1

Sujet:

Background: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).

Aliases: Ethe1 antibody, ETHE1 protein, mitochondrial precursor antibody, ETHE1_HUMAN antibody, ethylmalonic encephalopathy 1 antibody, Ethylmalonic encephalopathy protein 1 antibody, hepatoma subtracted clone one antibody, Hepatoma subtracted clone one protein antibody, HSCO antibody, mitochondrial antibody, Protein ETHE1 antibody, Protein ETHE1 mitochondrial antibody, YF13H12 antibody

UniProt: O95571