PODXL anticorps (AA 32-458)

N° du produit ABIN7163724

L’anticorps Lapin Polyclonal anti-PODXL a été validé pour WB, IHC, ELISA et IF. Il convient pour détecter PODXL dans des échantillons de Humain.

Aperçu rapide pour PODXL anticorps (AA 32-458) (ABIN7163724)

Antigène: PODXL (Podocalyxin-Like (PODXL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PODXL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-PODXL anticorps

Épitope: AA 32-458

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Podocalyxin protein (32-458AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PODXL

Antigène: PODXL (Podocalyxin-Like (PODXL))

Autre désignation: PODXL

Sujet:

Background: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Aliases: GCTM-2 antigen antibody, Gp2 antibody, Gp200 antibody, MGC138240 antibody, PC antibody, PCLP antibody, PCLP-1 antibody, PCLP1 antibody, Pcx antibody, Podocalyxin antibody, Podocalyxin like antibody, Podocalyxin like protein antibody, Podocalyxin-like protein 1 antibody, Podxl antibody, PODXL_HUMAN antibody

UniProt: O00592

Pathways: Tube Formation