Poliovirus Receptor anticorps (AA 220-345)

N° du produit ABIN7163737

Cet anticorps anti-Poliovirus Receptor est un anticorps Lapin Polyclonal détectant Poliovirus Receptor dans WB, IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour Poliovirus Receptor anticorps (AA 220-345) (ABIN7163737)

Antigène: Poliovirus Receptor (PVR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Poliovirus Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Poliovirus Receptor anticorps

Épitope: AA 220-345

Fonction: PVR Antibody

Réactivité croisée: Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Poliovirus receptor protein (220-345AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Poliovirus Receptor

Antigène: Poliovirus Receptor (PVR)

Autre désignation: PVR

Sujet:

Background: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.2 Publications

Aliases: CD155 antibody, CD155 antigen antibody, FLJ25946 antibody, HVED antibody, mE4 antibody, NECL 5 antibody, Necl-5 antibody, Necl5 antibody, Nectin like 5 antibody, Nectin like protein 5 antibody, Nectin-like protein 5 antibody, Ortholog of mouse Tage4 antibody, Poliovirus receptor antibody, PVR antibody, PVR_HUMAN antibody, PVS antibody, Taa1 antibody, Tage 4 antibody, TAGE4 antibody

UniProt: P15151

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome