PSME4 anticorps (AA 105-198)

N° du produit ABIN7164923

Cet anticorps Lapin Polyclonal détecte spécifiquement PSME4 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour PSME4 anticorps (AA 105-198) (ABIN7164923)

Antigène: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSME4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PSME4 anticorps

Épitope: AA 105-198

Fonction: PSME4 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Proteasome activator complex subunit 4 protein (105-198AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PSME4

Antigène: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Autre désignation: PSME4

Sujet:

Background: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Aliases: KIAA0077 antibody, PA200 antibody, Proteasome Activator 200 kDa antibody, Proteasome activator complex subunit 4 antibody, Proteasome activator PA200 antibody, PSME 4 antibody, psme4 antibody, PSME4_HUMAN antibody

UniProt: Q14997

Pathways: DNA Replication, Synthesis of DNA