RAPGEF2 anticorps (AA 1393-1498)

N° du produit ABIN7167104

Cet anticorps Lapin Polyclonal détecte spécifiquement RAPGEF2 dans ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour RAPGEF2 anticorps (AA 1393-1498) (ABIN7167104)

Antigène: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAPGEF2 est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Détail du produit anti-RAPGEF2 anticorps

Épitope: AA 1393-1498

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Rap guanine nucleotide exchange factor 2 protein (1393-1498AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RAPGEF2

Antigène: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Autre désignation: RAPGEF2

Sujet:

Background: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.

Aliases: CNrasGEF antibody, Cyclic nucleotide ras GEF antibody, KIAA0313 antibody, Neural RAP guanine nucleotide exchange protein antibody, nRap GEP antibody, NRAPGEP antibody, PDZ domain containing guanine nucleotide exchange factor 1 antibody, PDZ domain-containing guanine nucleotide exchange factor 1 antibody, PDZ GEF1 antibody, PDZ-GEF1 antibody, PDZGEF1 antibody, RA GEF antibody, RA-GEF-1 antibody, Rap guanine nucleotide exchange factor 2 antibody, Rapgef2 antibody, Ras/Rap1-associating GEF-1 antibody, RPGF2_HUMAN antibody

UniProt: Q9Y4G8

Pathways: Neurotrophin Signaling Pathway