TNIP1 anticorps (AA 526-636)

N° du produit ABIN7172251

Cet anticorps anti-TNIP1 est un anticorps Lapin Polyclonal détectant TNIP1 dans WB, ELISA, IHC et IF. Adapté pour Humain.

Aperçu rapide pour TNIP1 anticorps (AA 526-636) (ABIN7172251)

Antigène: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNIP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-TNIP1 anticorps

Épitope: AA 526-636

Réactivité croisée: Humain, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human TNFAIP3-interacting protein 1 protein (526-636AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TNIP1

Antigène: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Autre désignation: TNIP1

Sujet:

Background: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG, proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway, blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity, this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation, this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Aliases: ABIN 1 antibody, HIV-1 Nef-interacting protein antibody, hVAN antibody, KIAA0113 antibody, Naf1 antibody, Nef-associated factor 1 antibody, Nip40-1 antibody, TNFAIP3 interacting protein 1 antibody, TNFAIP3-interacting protein 1 antibody, TNIP-1 antibody, Tnip1 antibody, TNIP1_HUMAN antibody, VAN antibody, Virion-associated nuclear shuttling protein antibody

UniProt: Q15025

Pathways: Activation of Innate immune Response