UCHL3 anticorps (C-Term)

N° du produit ABIN7174370

Cet anticorps Lapin Polyclonal détecte spécifiquement UCHL3 dans IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour UCHL3 anticorps (C-Term) (ABIN7174370)

Antigène: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UCHL3 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-UCHL3 anticorps

Épitope: AA 1-220, C-Term

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L3 protein (1-220AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur UCHL3

Antigène: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Autre désignation: UCHL3

Sujet:

Background: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3\\\", and exhibits a preference towards \\\'Lys-48\\\'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Aliases: Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody, Ubiquitin thioesterase L3 antibody, Ubiquitin thiolesterase antibody, Ubiquitin thiolesterase L3 antibody, UCH L3 antibody, UCH-L3 antibody, UCHL3 antibody, UCHL3_HUMAN antibody

UniProt: P15374

Pathways: Feeding Behaviour, Positive Regulation of fat Cell Differentiation