VPS18 anticorps (AA 298-515)

N° du produit ABIN7175284

Cet anticorps anti-VPS18 est un anticorps Lapin Polyclonal détectant VPS18 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour VPS18 anticorps (AA 298-515) (ABIN7175284)

Antigène: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS18 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-VPS18 anticorps

Épitope: AA 298-515

Fonction: VPS18 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Vacuolar protein sorting-associated protein 18 homolog protein (298-515AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VPS18

Antigène: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Autre désignation: VPS18

Sujet:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).

Aliases: hVPS18 antibody, PEP3 antibody, Vacuolar protein sorting 18 antibody, Vacuolar protein sorting protein 18 antibody, Vacuolar protein sorting-associated protein 18 homolog antibody, vps18 antibody, VPS18_HUMAN antibody

UniProt: Q9P253

Pathways: Asymmetric Protein Localization