VPS18 anticorps (AA 298-515) (Biotin)

N° du produit ABIN7175285

Détail du produit anti-VPS18 anticorps (Biotin)

Antigène: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Épitope: AA 298-515

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS18 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Vacuolar protein sorting-associated protein 18 homolog protein (298-515AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VPS18

Antigène: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Autre désignation: VPS18 (VPS18 Produits)

Synonymes: anticorps MGC82750, anticorps VPS18, anticorps DDBDRAFT_0190675, anticorps DDBDRAFT_0234134, anticorps DDB_0190675, anticorps DDB_0234134, anticorps 9930024E13Rik, anticorps PEP3, anticorps chunp6929, anticorps fj35h10, anticorps hm:zehl0587, anticorps wu:fj35h10, anticorps VPS18, CORVET/HOPS core subunit, anticorps vacuolar protein sorting protein 18, anticorps VPS18, CORVET/HOPS core subunit S homeolog, anticorps subunit of the VPS-C complex, anticorps 7-fold repeat in clathrin and VPS proteins repeat-containing protein, anticorps vacuolar protein sorting 18 homolog (S. cerevisiae), anticorps VPS18 CORVET/HOPS core subunit, anticorps VPS18, anticorps Tc00.1047053506401.70, anticorps vps18.S, anticorps vps18, anticorps Vps18

Sujet:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).

Aliases: hVPS18 antibody, PEP3 antibody, Vacuolar protein sorting 18 antibody, Vacuolar protein sorting protein 18 antibody, Vacuolar protein sorting-associated protein 18 homolog antibody, vps18 antibody, VPS18_HUMAN antibody

UniProt: Q9P253

Pathways: Asymmetric Protein Localization