WIPI1 anticorps (AA 187-446)

N° du produit ABIN7175707

Cet anticorps anti-WIPI1 est un anticorps Lapin Polyclonal détectant WIPI1 dans WB, ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour WIPI1 anticorps (AA 187-446) (ABIN7175707)

Antigène: WIPI1 (WD Repeat Domain, phosphoinositide Interacting 1 (WIPI1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WIPI1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-WIPI1 anticorps

Épitope: AA 187-446

Réactivité croisée: Humain, Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human WD repeat domain phosphoinositide-interacting protein 1 protein (187-446AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur WIPI1

Antigène: WIPI1 (WD Repeat Domain, phosphoinositide Interacting 1 (WIPI1))

Autre désignation: WIPI1

Sujet:

Background: Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.

Aliases: ATG 18 antibody, ATG18 antibody, Atg18 protein homolog antibody, ATG18A antibody, FLJ10055 antibody, WD repeat domain phosphoinositide interacting 1 antibody, WD repeat domain phosphoinositide interacting protein 1 antibody, WD repeat domain phosphoinositide-interacting protein 1 antibody, WD40 repeat protein interacting with phosphoinositides of 49 kDa antibody, WD40 repeat protein interacting with phosphoInositides of 49 kDa antibody, WIPI 1 alpha antibody, WIPI 1 antibody, WIPI 49 antibody, WIPI 49 kDa antibody, WIPI-1 antibody, wipi1 antibody, WIPI1_HUMAN antibody, WIPI49 antibody

UniProt: Q5MNZ9

Pathways: Nuclear Hormone Receptor Binding, ER-Nucleus Signaling