XBP1 anticorps (AA 1-167) (FITC)

N° du produit ABIN7175885

Cet anticorps Lapin Polyclonal détecte spécifiquement XBP1 dans . Il présente une réactivité envers Humain.

Aperçu rapide pour XBP1 anticorps (AA 1-167) (FITC) (ABIN7175885)

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XBP1 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-XBP1 anticorps (FITC)

Épitope: AA 1-167

Fonction: XBP1 Antibody, FITC conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human X-box-binding protein 1 protein (1-167AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur XBP1

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Autre désignation: XBP1

Sujet:

Background: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).

Aliases: Tax responsive element binding protein 5 antibody, Tax-responsive element-binding protein 5 antibody, TREB5 antibody, X box binding protein 1 antibody, X box binding protein 2 antibody, X-box-binding protein 1 antibody, XBP 1 antibody, XBP-1 antibody, XBP1 antibody, XBP1_HUMAN antibody, XBP2 antibody

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response