Sortilin 1 anticorps (AA 610-754) (HRP)

N° du produit ABIN7179080

Cet anticorps Lapin Polyclonal détecte spécifiquement Sortilin 1 dans ELISA. Il présente une réactivité envers Rat.

Aperçu rapide pour Sortilin 1 anticorps (AA 610-754) (HRP) (ABIN7179080)

Antigène: Sortilin 1 (SORT1)

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sortilin 1 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-Sortilin 1 anticorps (HRP)

Épitope: AA 610-754

Réactivité croisée: Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Rat Sortilin protein (610-754AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Sortilin 1

Antigène: Sortilin 1 (SORT1)

Autre désignation: Sort1

Sujet:

Background: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Aliases: Sort1 antibody, Sortilin antibody, Glycoprotein 110 antibody, Gp110 antibody, Neurotensin receptor 3 antibody, NTR3 antibody

UniProt: O54861

Pathways: Neurotrophin Signaling Pathway