SOCS3 anticorps (AA 1-225) (HRP)

N° du produit ABIN7179084

L’anticorps Lapin Polyclonal anti-SOCS3 a été validé pour ELISA. Il convient pour détecter SOCS3 dans des échantillons de Rat.

Aperçu rapide pour SOCS3 anticorps (AA 1-225) (HRP) (ABIN7179084)

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS3 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-SOCS3 anticorps (HRP)

Épitope: AA 1-225

Réactivité croisée: Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Rat Suppressor of cytokine signaling 3 protein (1-225AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SOCS3

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: Socs3

Sujet:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Aliases: Socs3 antibody, Cish3Suppressor of cytokine signaling 3 antibody, SOCS-3 antibody, Cytokine-inducible SH2 protein 3 antibody

UniProt: O88583

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C